THE POTENTIAL OF VITAMIN A AS AN ADJUVANT AND PROFILACTIC THERAPY COMBINED WITH METOTREKSATS IN LOW RISK GESTASIONAL TROFOBLASTIC TUMORS
Methotrexate is used as the main chemotherapy agent in the management of Gestational Trophoblastic Neoplasia (GTN). Vitamin A can be used as prophylaxis as it has the potential to reduce the risk of transforming low risk GTN to become malignant. Therefore, this literature review aims to examine the mechanism of action and effectiveness of methotrexate and vitamin A in low-risk TTG therapy. Vitamin A plays a role in controlling cell proliferation by stopping the cell cycle in the G1 phase and promotes apoptosis. The combination of methotrexate and vitamin A in low-risk GTN therapy shows more effective results than single therapy with methotrexate.